Dalrymple writes about the teetotaling Reverend John Davis in the British Medical Journal (purchase required). His first paragraph no doubt speaks for a lot of us:

I hardly let a day go by without a glass or two of wine, and therefore I believe strongly (because I want to) in the J shaped curve of mortality versus alcohol consumption. Teetotallers are harming their health. As for moderation, its definition is clear: it is the habitual consumption of one drink more than the number I am drinking at the time.